RNA Details
Disease Name
silicosis
Tissue
lung
RNA Symbol
Skp2
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
Immunohistochemistry; qRT-PCR; Western Blot etc.
Target
NA
Pathway
NA
PubMed ID
Title
MicroRNA-205-5p targets E2F1 to promote autophagy and inhibit pulmonary fibrosis in silicosis through impairing SKP2-mediated Beclin1 ubiquitination
Year
2021
Function
"To further verify whether SKP2 was elevated in early silicosis, we analysed the SKP2 mRNA levels in the afore-mentioned tissues by RT-qRT-PCR and confirmed the presence of a significantly increased SKP2 expression pattern in the alveolar tissues of early silicosis."